DrosDel Immunity Panel

Name	VDRC Id	Library	Sub-Category	Genotype	Comment	Construct Id	Publication	Provider Scientist	Provider Organization	Gene Symbol	Synonyms	Comment	Gene Name	Keywords	Price (net)
349903	349903	DD-Im	mutants	w[1118]; NimC1[Delta]; eater[Delta]	BL4. NimC1-delta and Eater-delta mutations were generated by homologous recombination (both genes are replaced by a w+ cassette), isogenized in the w[1118] DrosDel genetic background. NimC1-delta, Eater-delta have strongly reduced phagocytosis ability and defective hemocyte sessility due to the absence of Eater. While NimC1-delta, Eater-delta larvae have more hemocytes, NimC1-delta, Eater-delta adults tend to have decreased hemocyte number over time. This line can be used to assess the function of phagocytosis, although it likely impacts other processes. Of note, the non-iso NimC1, Eater flies are not isogenized in the DrosDel background due to developing sterility problems.	349903	Bretscher et al., Biol Open (2015)	Bruno Lemaitre with the help of Mark Hanson	EPFL	NimC1	BG:DS00180.10 CG6124 CT25688 DrosDel Immunity panel Nim NimC NimC1 Nimrod C1 NimrodC1 P1 eater nimC1 nimrod nimrod C1 nimrodC1	BL4. NimC1-delta and Eater-delta mutations were generated by homologous recombination (both genes are replaced by a w+ cassette), isogenized in the w[1118] DrosDel genetic background. NimC1-delta, Eater-delta have strongly reduced phagocytosis ability and defective hemocyte sessility due to the absence of Eater. While NimC1-delta, Eater-delta larvae have more hemocytes, NimC1-delta, Eater-delta adults tend to have decreased hemocyte number over time. This line can be used to assess the function of phagocytosis, although it likely impacts other processes. Of note, the non-iso NimC1, Eater flies are not isogenized in the DrosDel background due to developing sterility problems.	Nimrod C1	DrosDel Immunity panel	Sign In to show prices
349911	349911	DD-Im	mutants	w[1118]; Def[SK3], AttC[Mi], Dro-AttAB[SK2], Mtk[R1], Dpt[SK1]/CyO; Drs[R1], AttD[SK1]/TM6C, Sb[1]	BL12. DeltaAMP10: 7 deletions removing 10 Antimicrobial peptides genes, all isogenized in the w[1118] DrosDel genetic background. DroAtt removes Drosocin locus (2 peptides (Hanson et al. 2022)) and Attacin A and B. The MtkR1 and DrsR1 loci each carry one w+ transgene, and the AttCMi mutation also causes GFP to be expressed in the eyes, ocelli, and occasionally the gut. Balancers floating: CyO; TM6C, Sb (not Tubby).	349911	Hanson et al., eLife 8 (2019)	Bruno Lemaitre with the help of Mark Hanson	EPFL	AttA	143607_at AHA ATT ATTA Att Att A Att-A AttA AttC AttD AttaA Attacin Attacin A Attacin-A Attacin-A precursor Attacin-A AttacinA AttacinA Attackin BcDNA:LP05763 CecA-C DEF DIM 26 Def Defe	BL12. DeltaAMP10: 7 deletions removing 10 Antimicrobial peptides genes, all isogenized in the w[1118] DrosDel genetic background. DroAtt removes Drosocin locus (2 peptides (Hanson et al. 2022)) and Attacin A and B. The MtkR1 and DrsR1 loci each carry one w+ transgene, and the AttCMi mutation also causes GFP to be expressed in the eyes, ocelli, and occasionally the gut. Balancers floating: CyO; TM6C, Sb (not Tubby).	Attacin-A	DrosDel Immunity panel	Sign In to show prices
349912	349912	DD-Im	mutants	w[1118]; Def[SK3], AttC[Mi], Dro-AttAB[SK2], Mtk[R1], Dpt[SK1]/CyO; Drs[R1], AttD[SK1], CecA-C[Delta]/TM6C, Sb[1]	BL13. DeltaAMP14: 8 deletions removing 14 Antimicrobial peptides genes (AMP10 + deletion of Cecropin locus), all isogenized in the w[1118] DrosDel genetic background. DroAtt removes Drosocin locus (2 peptides (Hanson et al., 2022)) and Attacin A and B. The MtkR1 and DrsR1 loci each carry one w+ transgene, and the AttCMi mutation also causes GFP to be expressed in the eyes, ocelli, and occasionally the gut. The CecA-C mutation also produces DsRed in the eyes, ocelli, and abdomen. Balancers floating: CyO; TM6C, Sb (not Tubby).	349912	Hanson et al., eLife 8 (2019)	Bruno Lemaitre with the help of Mark Hanson	EPFL	AttA	143607_at AHA ATT ATTA Att Att A Att-A AttA AttC AttD AttaA Attacin Attacin A Attacin-A Attacin-A precursor Attacin-A AttacinA AttacinA Attackin BcDNA:LP05763 CecA-C DEF DIM 26 Def Defe	BL13. DeltaAMP14: 8 deletions removing 14 Antimicrobial peptides genes (AMP10 + deletion of Cecropin locus), all isogenized in the w[1118] DrosDel genetic background. DroAtt removes Drosocin locus (2 peptides (Hanson et al., 2022)) and Attacin A and B. The MtkR1 and DrsR1 loci each carry one w+ transgene, and the AttCMi mutation also causes GFP to be expressed in the eyes, ocelli, and occasionally the gut. The CecA-C mutation also produces DsRed in the eyes, ocelli, and abdomen. Balancers floating: CyO; TM6C, Sb (not Tubby).	Attacin-A	DrosDel Immunity panel	Sign In to show prices
349913	349913	DD-Im	mutants	w[1118]; Def[SK3]; Df(3R)CecA-C[Delta]/TM6, Sb[1]	BL14. DeltaAMP Group A: 2 deletions removing the Defensin and the Cecropin Locus (4 genes), all isogenized in the w[1118] DrosDel genetic background. The polymorphism at the Bulletin locus is Alanine.	349913	Hanson et al., eLife 8 (2019)	Bruno Lemaitre with the help of Mark Hanson	EPFL	Def	143607_at CecA-C DEF DIM 26 Def Defencin Defensin Defensin precursor Definsin DeltaAMP Group A Dfn DrosDel Immunity panel def defensin	BL14. DeltaAMP Group A: 2 deletions removing the Defensin and the Cecropin Locus (4 genes), all isogenized in the w[1118] DrosDel genetic background. The polymorphism at the Bulletin locus is Alanine.	Defensin	DrosDel Immunity panel	Sign In to show prices
349914	349914	DD-Im	mutants	w[1118]; Mtk[R1]; Drs[R1]	BL15. DeltaAMP Group C: 2 mutations removing 2 antifungal peptides (2 genes), all isogenized in the w[1118] DrosDel genetic background.	349914	Hanson et al., eLife 8 (2019)	Bruno Lemaitre with the help of Mark Hanson	EPFL	Mtk	BcDNA:RH07954 DIM 17 DeltaAMP Group C DrosDel Immunity panel Drosophila Immune induced molecule 17 Drs METCH Mek Metc Metch Metchnikowin Metchnikowin A Metchnikowin B Metchnikowin precursor Metchnikowine Mtk	BL15. DeltaAMP Group C: 2 mutations removing 2 antifungal peptides (2 genes), all isogenized in the w[1118] DrosDel genetic background.	Metchnikowin	DrosDel Immunity panel	Sign In to show prices
349915	349915	DD-Im	mutants	w[1118]; AttC[Mi], DroAtt[SK2], Dpt[SK1]; AttD[SK1]	BL16. DeltaAMP Group B: 4 mutations removing the two Diptericin, the 4 Attacins and Drosocin, all isogenized in the w[1118] DrosDel genetic background. DroAtt removes the Drosocin locus (two peptides) and Attacin A and B (Hanson et al., 2022).	349915	Hanson et al., eLife 8 (2019)	Bruno Lemaitre with the help of Mark Hanson	EPFL	AttC	Att AttC AttD Attacin Attacin C Attacin-C Attacin-C precursor AttacinC Attackin C DIM 16 DIM-16 DeltaAMP Group B Dpt DroAtt DrosDel Immunity panel Drosophila Immune induced molecule 16 MPAC att att	BL16. DeltaAMP Group B: 4 mutations removing the two Diptericin, the 4 Attacins and Drosocin, all isogenized in the w[1118] DrosDel genetic background. DroAtt removes the Drosocin locus (two peptides) and Attacin A and B (Hanson et al., 2022).	Attacin-C	DrosDel Immunity panel	Sign In to show prices
349935	349935	DD-Im	mutants	w[1118]; TotM[jp1621]; TotAZ[SK6], TotX[jp44]	BL36. A fly line, called TotXMAZ, carrying 1 mutation affecting TotM, 1 mutation affecting TotX and a deletion removing the TotA, TotB, TotC and TotZ genes, isogenized in the w[1118] DrosDel genetic background.	349935	Rommelaere et al., Curr Biol (2024)	Bruno Lemaitre with the help of Mark Hanson	EPFL	TotM	DrosDel Immunity panel TOTM Tot M TotA TotB TotC TotM TotX TotZ Turandot Turandot M tot tot, totM	BL36. A fly line, called TotXMAZ, carrying 1 mutation affecting TotM, 1 mutation affecting TotX and a deletion removing the TotA, TotB, TotC and TotZ genes, isogenized in the w[1118] DrosDel genetic background.	Turandot M	DrosDel Immunity panel	Sign In to show prices