349903
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SKU
DD-IM-349903
| VDRC Id | 349903 |
|---|---|
| Library | DD-Im |
| Sub-Category | mutants |
| Status | available |
| Comment | BL4. NimC1-delta and Eater-delta mutations were generated by homologous recombination (both genes are replaced by a w+ cassette), isogenized in the w[1118] DrosDel genetic background. NimC1-delta, Eater-delta have strongly reduced phagocytosis ability and defective hemocyte sessility due to the absence of Eater. While NimC1-delta, Eater-delta larvae have more hemocytes, NimC1-delta, Eater-delta adults tend to have decreased hemocyte number over time. This line can be used to assess the function of phagocytosis, although it likely impacts other processes. Of note, the non-iso NimC1, Eater flies are not isogenized in the DrosDel background due to developing sterility problems. |
| Construct Id | 349903 |
| Genotype | w[1118]; NimC1[Delta]; eater[Delta] |
| Gene Symbol | NimC1 |
| Gene Name | Nimrod C1 |
| Synonyms | BG:DS00180.10 CG6124 CT25688 DrosDel Immunity panel Nim NimC NimC1 Nimrod C1 NimrodC1 P1 eater nimC1 nimrod nimrod C1 nimrodC1 |
| Keywords | DrosDel Immunity panel |
| Inserted Chromosome | 2;3 |
| Viability | viable |
| Publication | Bretscher et al., Biol Open (2015) |
| Provider Scientist | Bruno Lemaitre with the help of Mark Hanson |
| Provider Organization | EPFL |