DrosDel Immunity Panel
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| Name | VDRC Id | Library | Sub-Category | Genotype | Comment | Construct Id | Publication | Provider Scientist | Provider Organization | Gene Symbol | FlyBase gene number | Synonyms | Sequence | RRID | Comment | Gene Name | Keywords | Price (net) | Add to Cart | ||
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| 349902 |
349902
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DD-Im
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mutants
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w[1118]; PPO1[Delta], PPO2[Delta]
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BL3. PPO1-delta and PPO2-delta mutations were generated by homologous recombination (homologous replacement of PPO1 sequences with w[+]), isogenized in the w[1118] DrosDel genetic background. PPO1-Delta, PPO2-delta show no hemolymphatic melanization after injury. PPO3 in lamellocytes can still contribute to melanization around wasp eggs (Dudzic et al, BMC Biol 2015)
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349902
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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PPO1
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A1
A[[1]] Bc Black Cell CG5779 CG8193 Diphenol oxidase A1 subunit DmPPO1 DmePPOA1 Dox-A1 DoxA1 DrosDel Immunity panel Monophenol oxidase Monophenoloxidase Mox PO PO A1 PO54 PPO PPO-1 PPO-A1 PP |
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BL3. PPO1-delta and PPO2-delta mutations were generated by homologous recombination (homologous replacement of PPO1 sequences with w[+]), isogenized in the w[1118] DrosDel genetic background. PPO1-Delta, PPO2-delta show no hemolymphatic melanization after injury. PPO3 in lamellocytes can still contribute to melanization around wasp eggs (Dudzic et al, BMC Biol 2015)
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Prophenoloxidase 1
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DrosDel Immunity panel
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| 349918 |
349918
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DD-Im
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mutants
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w[1118]; Dro[SK4]
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BL19. A mutation affecting the whole Drosocin locus, isogenized in the w[1118] DrosDel genetic background.
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349918
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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Dro
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143609_at
AttA AttB BcDNA:RH31634 DIM 11 DIM 15 DIM 9 DIM-15 DROC Drc Dro Dro1 Dros DrosDel Immunity panel Drosocin Drosocin precursor Drosophila Immune induced molecule 11 Drosophila Immune induced molec |
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BL19. A mutation affecting the whole Drosocin locus, isogenized in the w[1118] DrosDel genetic background.
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Drosocin
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DrosDel Immunity panel
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| 349920 |
349920
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DD-Im
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mutants
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w[1118]; BaraA[Delta]{dsRed}
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BL21. Complete deletion of BaramicinA locus, isogenized in the w[1118] DrosDel genetic background. This mutation retains the full gene region of CG30059, but replaces sequence directly downstream with a DsRed construct. Note that this genotype is lacking both CG18279 (BaraA1) and CG33470 (BaraA2), and also lacks CG18278 as the mutation was generated in a background that never had the BaraA1 + CG18278 locus duplication in the first place. i.e. generated in a background with only CG33470 and CG30059.
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349920
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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BaraA1
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BaraA
BaraA1 BaraA2 CG18278 CG18279 Daisho1 Daisho2 DrosDel Immunity panel Group D IM10 IM12 IM13 IM22 IM24 IM5 IM6 IM8 |
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BL21. Complete deletion of BaramicinA locus, isogenized in the w[1118] DrosDel genetic background. This mutation retains the full gene region of CG30059, but replaces sequence directly downstream with a DsRed construct. Note that this genotype is lacking both CG18279 (BaraA1) and CG33470 (BaraA2), and also lacks CG18278 as the mutation was generated in a background that never had the BaraA1 + CG18278 locus duplication in the first place. i.e. generated in a background with only CG33470 and CG30059.
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Baramicin A1
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DrosDel Immunity panel
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| 349921 |
349921
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DD-Im
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mutants
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w[1118]; DptA[Delta-822]
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BL22. A premature stop mutation affecting the DptA locus, derived from the strain DGRP-822, isogenized in the w[1118] DrosDel genetic background.
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349921
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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DptA
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143443_at
DIPT DPT Dep Dip Dipt DiptA Diptericin Diptericin A Diptericin precursor Diptericin-A DiptericinA Dpt DptA DptB DrosDel Immunity panel dip dipt diptericin diptericin A dpt |
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BL22. A premature stop mutation affecting the DptA locus, derived from the strain DGRP-822, isogenized in the w[1118] DrosDel genetic background.
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Diptericin A
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DrosDel Immunity panel
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| 349922 |
349922
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DD-Im
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mutants
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w[1118]; DptB[KO]
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BL23. Deletion of the DptB locus (Barajas-Azpeleta, PLOS Gen, 2018), isogenized in the w[1118] DrosDel genetic background. This line induces the related gene DptA to a lesser extent compared to the DrosDel background, and so within this immune mutant panel, it may most accurately be considered a hypomorph for DptA alongside being fully null for DptB.
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349922
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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DptB
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147473_at
BcDNA:RH29451 DiptB Diptercin B Diptericin Diptericin B Diptericin-B DiptericinB Dpt DptB DrosDel Immunity panel diptericin B diptericin-like protein diptericin-like proteinm dpt B dptB dptlp |
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BL23. Deletion of the DptB locus (Barajas-Azpeleta, PLOS Gen, 2018), isogenized in the w[1118] DrosDel genetic background. This line induces the related gene DptA to a lesser extent compared to the DrosDel background, and so within this immune mutant panel, it may most accurately be considered a hypomorph for DptA alongside being fully null for DptB.
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Diptericin B
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DrosDel Immunity panel
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| 349923 |
349923
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DD-Im
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mutants
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w[1118]; DptA[S69R-4]
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BL24. Serine-arginine polymorphism at residue 69 of DptA (derived from DGRP-38), isogenized in the w[1118] DrosDel genetic background.
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349923
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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DptA
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143443_at
DIPT DPT Dep Dip Dipt DiptA Diptericin Diptericin A Diptericin precursor Diptericin-A DiptericinA Dpt DptA DptB DrosDel Immunity panel dip dipt diptericin diptericin A dpt |
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BL24. Serine-arginine polymorphism at residue 69 of DptA (derived from DGRP-38), isogenized in the w[1118] DrosDel genetic background.
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Diptericin A
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DrosDel Immunity panel
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| 349925 |
349925
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DD-Im
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mutants
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w[1118]; Mtk[R1]
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BL26. A deletion removing the Mtk locus (generated by homologous recombination, contains a w+ gene), isogenized in the w[1118] DrosDel genetic background.
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349925
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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Mtk
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BcDNA:RH07954 DIM 17 DeltaAMP Group C DrosDel Immunity panel Drosophila Immune induced molecule 17 Drs METCH Mek Metc Metch Metchnikowin Metchnikowin A Metchnikowin B Metchnikowin precursor Metchnikowine Mtk |
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BL26. A deletion removing the Mtk locus (generated by homologous recombination, contains a w+ gene), isogenized in the w[1118] DrosDel genetic background.
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Metchnikowin
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DrosDel Immunity panel
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| 349926 |
349926
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DD-Im
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mutants
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w[1118]; Dpt[SK1]/CyO
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BL27. A deletion removing DptA and DptB, isogenized in the w[1118] DrosDel genetic background. Homozygous viable, so CyO may be absent or floating.
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349926
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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DptA
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143443_at
DIPT DPT Dep Dip Dipt DiptA Diptericin Diptericin A Diptericin precursor Diptericin-A DiptericinA Dpt DptA DptB DrosDel Immunity panel dip dipt diptericin diptericin A dpt |
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BL27. A deletion removing DptA and DptB, isogenized in the w[1118] DrosDel genetic background. Homozygous viable, so CyO may be absent or floating.
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Diptericin A
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DrosDel Immunity panel
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| 349927 |
349927
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DD-Im
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mutants
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w[1118]; Df(2R)Dro-AttAB[SK2]
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BL28. A deletion removing Drosocin locus, AttA and AttB, isogenized in the w[1118] DrosDel genetic background.
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349927
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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Dro
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143609_at
AttA AttB BcDNA:RH31634 DIM 11 DIM 15 DIM 9 DIM-15 DROC Drc Dro Dro1 Dros DrosDel Immunity panel Drosocin Drosocin precursor Drosophila Immune induced molecule 11 Drosophila Immune induced molec |
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BL28. A deletion removing Drosocin locus, AttA and AttB, isogenized in the w[1118] DrosDel genetic background.
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Drosocin
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DrosDel Immunity panel
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| 349928 |
349928
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DD-Im
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mutants
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w[1118]; Df(2R)Bom[Delta55C]/CyO
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BL29. A 9-kb deletion removing 10 genes at the Bomanin 55C locus, isogenized in the w[1118] DrosDel genetic background. The deletion was generated by Clemmons et al., PLOS Path, 2015. CyO floating.
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349928
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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BomT1
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Bom202
Bom55C BomBc1 BomBc2 BomS1 BomS2 BomS3 BomS4 BomS5 BomS6 BomT2 CG42737 DMG8-chr2R.26.014 DrosDel Immunity panel chr2R.1731 |
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BL29. A 9-kb deletion removing 10 genes at the Bomanin 55C locus, isogenized in the w[1118] DrosDel genetic background. The deletion was generated by Clemmons et al., PLOS Path, 2015. CyO floating.
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Bomanin Tailed 1
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DrosDel Immunity panel
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| 349929 |
349929
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DD-Im
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mutants
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w[1118]; Mi{ET1}AttC[MB05438]
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BL30. A Minos insertion affecting Attacin C, isogenized in the w[1118] DrosDel genetic background.
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349929
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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AttC
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Att
AttC AttD Attacin Attacin C Attacin-C Attacin-C precursor AttacinC Attackin C DIM 16 DIM-16 DeltaAMP Group B Dpt DroAtt DrosDel Immunity panel Drosophila Immune induced molecule 16 MPAC att att |
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BL30. A Minos insertion affecting Attacin C, isogenized in the w[1118] DrosDel genetic background.
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Attacin-C
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DrosDel Immunity panel
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| 349931 |
349931
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DD-Im
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mutants
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w[1118]; Def[SK3]
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BL32. A deletion removing the Defensin gene, first published in Parvy et al. (2019; eLife) having been backcrossed into the w[1118] DrosDel genetic background. A revisiting of this allele in Hanson et al. (2022; Proc R Soc B) later realized the Def[SK3]-containing chromosome had an alternate version of the Buletin allele, and so this was further isogenized to ensure the Buletin locus had an alanine allele matching the w[1118] DrosDel isogenic background, and the resulting strain published in Hanson et al. (2023; Dis Mod Mech). The correction of the Buletin allele to be alanine (matching the DrosDel background) affects the interpretation of Def[SK3] effects in previous literature pertaining to antibacterial defence in minor ways.
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349931
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Bruno Lemaitre with the help of Mark Hanson
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EPFL
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Def
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143607_at
AHA ATT ATTA Att Att A Att-A AttA AttC AttD AttaA Attacin Attacin A Attacin-A Attacin-A precursor Attacin-A AttacinA AttacinA Attackin BcDNA:LP05763 CecA-C DEF DIM 26 Def Defe |
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BL32. A deletion removing the Defensin gene, first published in Parvy et al. (2019; eLife) having been backcrossed into the w[1118] DrosDel genetic background. A revisiting of this allele in Hanson et al. (2022; Proc R Soc B) later realized the Def[SK3]-containing chromosome had an alternate version of the Buletin allele, and so this was further isogenized to ensure the Buletin locus had an alanine allele matching the w[1118] DrosDel isogenic background, and the resulting strain published in Hanson et al. (2023; Dis Mod Mech). The correction of the Buletin allele to be alanine (matching the DrosDel background) affects the interpretation of Def[SK3] effects in previous literature pertaining to antibacterial defence in minor ways.
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Defensin
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DrosDel Immunity panel
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